A cutting-edge scientific achievement in novel high-efficiency deamination technology, developed by a new materials company based in Heilongjiang, China, was officially published in the top international academic journal Nature in early November 2025. Hailed as a world-class advancement in drug synthesis and R&D, this innovation has garnered widespread attention for its potential to reshape molecular modification across multiple high-value industries.
The core breakthrough lies in the development of a direct deamination strategy mediated by N-nitroamine formation. This pioneering approach provides a new pathway for the precise modification of heterocyclic compounds and aniline derivatives—key building blocks in drug development and fine chemical synthesis. Unlike traditional deamination methods that often rely on unstable intermediates or harsh reaction conditions, the N-nitroamine-mediated technology offers a paradigm shift in efficiency and versatility.
Three standout advantages define this method: universality, high efficiency, and operational simplicity. It exhibits broad applicability across a wide range of target molecules, eliminating the limitations of conventional techniques that are restricted by substrate structure or amino group position. The reaction proceeds under mild conditions, avoiding the need for toxic catalysts or extreme temperature/pressure controls, which significantly reduces safety risks and environmental impact. Most notably, the technology has successfully completed kilogram-scale pilot production verification, demonstrating its feasibility for large-scale industrial application and laying a solid foundation for commercialization.
The application value of this innovation extends far beyond pharmaceuticals. It is expected to gain widespread adoption in chemical engineering, advanced materials, and pesticide synthesis. In drug development, it will streamline the production of key intermediates, accelerating the R&D process of small-molecule drugs such as anticancer agents and neurological medications. In the chemical and materials sectors, it enables greener and more cost-effective synthesis of specialty chemicals and functional materials. For pesticide manufacturing, it offers a more sustainable approach to producing high-performance intermediates while complying with stringent environmental regulations.
This breakthrough not only addresses long-standing challenges in molecular modification but also reinforces China’s position in cutting-edge chemical innovation. As industrialization progresses, the technology is poised to drive efficiency gains and cost reductions across multiple sectors, marking a significant step forward in the global shift toward greener and more sustainable manufacturing practices.
Post time: Nov-14-2025