Core Breakthrough
On October 28, the direct deamination functionalization technology for aromatic amines developed by Zhang Xiaheng’s team from the Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences (HIAS, UCAS) was published in Nature. This technology solves the safety and cost challenges that have plagued the chemical industry for 140 years.
Technical Highlights
1.Abandons the traditional diazonium salt process (prone to explosion and high pollution), achieving efficient C-N bond conversion through N-nitroamine intermediates.
2.Requires no metal catalysts, reducing production costs by 40%-50%, and has completed kilogram-scale verification.
3.Applicable to almost all pharmaceutical heteroaromatic amines and aniline derivatives, without being restricted by the position of the amino group.
Industrial Impact
1.Pharmaceutical industry: As the key skeleton of 70% of small-molecule drugs, the synthesis of intermediates for anticancer drugs and antidepressants becomes safer and more economical. Enterprises like Baicheng Pharmaceutical are expected to see a 40%-50% cost reduction.
2.Dyestuff industry: Leading enterprises such as Zhejiang Longsheng, which hold a 25% market share in aromatic amines, resolve the explosion risk that has long restricted capacity expansion.
3.Pesticide industry: Enterprises including Yangnong Chemical will experience a significant reduction in the cost of pesticide intermediates.
4.Electronic materials: Promotes the green synthesis of special functional materials.
Capital Market Reaction
On November 3, the chemical sector strengthened against the market trend, with the aromatic amine segment leading the gains and related concept stocks showing full vitality.
Post time: Nov-06-2025